The focus of this site is:-

1) The Fluids of the Inner Ear, perilymph and endolymph

2) The Barriers of the Ear, that control how substances enter and leave

3) Local Drug Delivery to the Inner Ear

4) Computer Simulations of Drug Distribution in the Ear

Iillustrations at the top are:

(Left) A guinea pig inner ear in which the perilymphatic spaces were filled with orange latex and the endolymph with dark blue latex, then dissected open. Back in the 1980's, this was our first 3D view of the inner ear fluid spaces.

(Middle) Digital 3D reconstruction of the fluid spaces of the guinea pig ear. Yellow:scala tympani; Green: scala vestibuli; Blue:endolymph; Cyan: round window; Brown: stapes.

(Right) A mid-modiolar histologic section through the guinea pig ear showing the membranous and cellular structures inside.

Some background on the origins of this site:

When the internet became popular in 1995, we set up a website, hosted by Washington University, containing information about the inner ear. Those pages titled "Cochlear Fluids Research Laboratory" are still archived at web.archive.org. That website was taken down in November 2017.

 

The current website has been personally-generated and is not affiliated in any way with Washington University. The content is similar to our previous site but now includes more detail relevant to drug delivery to the inner ear.